The goal of the US Deprescribing Research Network (USDeN) is to develop and disseminate evidence about deprescribing for older adults, and in doing so to help improve medication use among older adults and the outcomes that are important to them. Funded by the US National Institute on Aging, the network is a community of people united by a shared interest in improving research on deprescribing for older adults. The network’s key activities are designed to provide resources and supports that will catalyze expansion of the quality, quantity, and ultimate impact of deprescribing research, and to promote mutual learning and collaboration that is essential to this goal. Network activities are oriented around 4 cores and a series of working groups: