Highlights

Goyal P, Safford M, Hilmer SN, et al. N-of-1 Trials to Facilitate Evidence-Based Deprescribing: Rationale and Case Study [published online ahead of print, 2022 Jun 15]. Br J Clin Pharmacol. 2022;10.1111/bcp.15442. doi:10.1111/bcp.15442 Junior Investigator Intensive scholar Parag Goyal and a team of researchers recently published a narrative review on deprescribing-N-of-1 trials. N-of-1 trials compare treatment […]

Green AR, Aschmann H, Boyd CM, Schoenborn N. Association between willingness to deprescribe and health outcome priorities among U.S. older adults: Results of a national survey [published online ahead of print, 2022 Jun 6]. J Am Geriatr Soc. 2022;10.1111/jgs.17917. doi:10.1111/jgs.17917 A team led by Dr. Ariel Green, who received a pilot award from the US

Bayliss, EA, Albers, K, Gleason, K, et al. Recommendations for outcome measurement for deprescribing intervention studies. J Am Geriatr Soc. 2022; 1- 11. doi:10.1111/jgs.17894 The US Deprescribing Research Network’s very own Measures Workgroup recently published recommendations for selecting and using outcomes for deprescribing interventions in the Journal of the American Geriatrics Society. Authors point to

Thompson W, Jarbøl D, Nielsen JB, Haastrup P, Pedersen LB. GP preferences for discussing statin deprescribing: a discrete choice experiment. Fam Pract. 2022;39(1):26-31. doi:10.1093/fampra/cmab075 Although there is ample evidence on the benefits of deprescribing for older patients, providers’ deprescribing-related communication preferences are less understood. Given that clinicians often have the greatest influence on patients’ deprescribing

Moriarty F, Thompson W, Boland F. Methods for evaluating the benefit and harms of deprescribing in observational research using routinely collected data. Res Social Adm Pharm. 2022;18(2):2269-2275. doi:10.1016/j.sapharm.2021.05.007 Recent advances in pharmacoepidemiology have allowed researchers to apply randomized controlled trial (RCT) principles to observational data. These advances have resulted in better estimates of medication harms

McDonald EG, Wu PE, Rashidi B, et al. The MedSafer Study-Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial [published online ahead of print, 2022 Jan 18]. JAMA Intern Med. 2022;10.1001/jamainternmed.2021.7429. doi:10.1001/jamainternmed.2021.7429 A team of researchers investigated the impact of MedSafer, an electronic deprescribing tool based on electronic health record

 McConeghy, K. W., Cinque, M., White, E. M., Feifer, R. A., Blackman, C., Mor, V., Gravenstein, S., & Zullo, A. R. (2021). Lessons for deprescribing from a nonessential medication hold policy in US nursing homes. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.17512   The COVID-19 pandemic caused nursing homes to rapidly adapt to new care

Budnitz DS, Shehab N, Lovegrove MC, Geller AI, Lind JN, Pollock DA. US Emergency Department Visits Attributed to Medication Harms, 2017-2019. JAMA. 2021;326(13):1299–1309. doi:10.1001/jama.2021.13844   Medication risk assessment should account for both therapeutic use as well as nontherapeutic use. Therapeutic use refers to medications taken as prescribed, while nontherapeutic use refers to unsupervised medication use, medication misuse

Niznik, J.D., Aspinall, S.L., Hanson, L.C. et al. Patterns of Oral Bisphosphonate Deprescribing in Older Nursing Home Residents with Dementia. Osteoporos Int. Sep 2021. https://doi.org/10.1007/s00198-021-06141-9 Dr. Niznik and colleagues determines the incidence of deprescribing bisphosphonates among nursing home residents with dementia, and identified factors associated with deprescribing bisphosphonates. Dr. Niznik and team point to the

Rochon, PA et al. Polypharmacy, Inappropriate Prescribing, and Deprescribing in Older People: Through a Sex and Gender Lens. Lancet Healthy Longev. 2021 May; 2(5) e290-300. DOI: https://doi.org/10.1016/S2666-7568(21)00054-4 Appropriate prescribing and medication optimization is important as older adults age, but little attention has been paid to the sex and gender differences of prescribing in older age.